The Project


Development and detailed Characterization of a Cohort for Community Acquired Pneumonia in Childhood and Adolescence

Study Rationale
Worldwide, respiratory infections and community acquired pneumonia (CAP) belong to the leading causes for childhood morbidity and mortality, and pneumonia accounts for around 20% of infant deaths in children aged 0 to 5 years. In spite of this high morbidity and mortality, valid data on regional, national and global causes, diagnostics and treatment of childhood CAP is scarce. Most available information on frequency, etiology, course and management of pediatric pneumonia was derived from studies in small and specialized patient cohorts (e.g. only in infants or only in hospitalized patients). Current recommendations for the management of childhood pneumonia are mainly based on study data from the 1980ies and 1990ies, and the evidence level of these recommendations is low. By contrast, a plethora of data and recently updated guidelines for the management of adult CAP exist. Major contributions to the current knowledge on adult CAP in Europe were made by the German competence network for CAP (CAPNETZ). The adult CAPNETZ cohort represents one of the largest and best characterized pneumonia cohorts in the world. So far, information on more than 10.000 CAP cases was implemented into the CAPNETZ cohort. The current German guideline on CAP management in adult patients is mainly based on data obtained through CAPNETZ. Since 2013, CAPNETZ is an associated partner of the German Center for Lung Research (DZL) and collaborates nationwide with clinical institutions in order to optimize data and biomaterial collection and clinical study conductance in CAP research. 


The aim of the proposed project is to improve the management of CAP in pediatric patients. Building up a regional, detail-characterized cohort of community-acquired pneumonia in children and adolescents shall provide relevant clinical data, diagnostic parameters, and biomaterials. Study objectives are:

  1. Identifying clinical diagnostic criteria of CAP in childhood and adolescence
  2. Establishment of an appropriate risk stratification
  3. Demonstrating clinical prognostic markers
  4. Biomarker identification for the prognosis of patients


Pilot study in approximately 5 study sites

Study Population:
Recruitment of 100 children and youths between 0 and 17 years for the pilot study

pedCAPNETZ portal